Disease is the experience which brings a journey of all unexpected suffering events. Its never limited to just patient affected by disease but also involves his or her surroundings. If we give wish to any human being health would be the first pray for all. We believe in science but there are so many factors responsible to generate miracles from some of the most major illness. Gastro Intestinal and Liver Pancreas Biliary System is the biggest inter related organs and physiology of our body. It can be involved by any minor to major problems because of infections, genetic problem and cancers. Surgery is never first choice for even clinicians. But one might need to undergo cut for saving life. We tried to enlighten this struggle of many people who have been winner from most difficult task to defeat major illness and surgery. Success “story” is not just imagination of this painful condition of mind its reflection of the experience and outcome from most unforgettable moments bringing smile to whole family.